Nuts and Bolts: Different Variations.

GCU encourages card designs in variations to address differences like age, gender, hair color, skin color. These would go in the same functional category and be identified with appropriate metadata (card title, keywords, artist notes) to note the unique or different element of the card and help shoppers find exactly what they are searching for.

A card design redesigned with a meaningful variance (meaningful to shoppers to purchase one over the over) is permitted in the image re-use policy, and is permitted in up to 3 different variations.  See here on Leveraging Designs.

Here are some great examples: